Reproduction Abstracts

Mitochondrial DNA (mtDNA) mutations are maternally inherited and are associated with a broad range of debilitating and fatal diseases. Reproductive technologies designed to uncouple the inheritance of mtDNA from nuclear DNA may enable affected women to have a genetically related child with a greatly reduced risk of mtDNA disease. To this end, we have performed preclinical studies on pronuclear transplantation (PNT). Surprisingly, techniques used in proof of concept studies inv...